Opioid-free total intravenous anesthesia with propofol, dexmedetomidine and lidocaine infusions for laparoscopic cholecystectomy: a prospective, randomized, double-blinded study


Bakan M., Umutoglu T., Topuz U., UYSAL H., Bayram M., Kadioglu H., ...More

REVISTA BRASILEIRA DE ANESTESIOLOGIA, vol.65, pp.191-199, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 65 Issue: 3
  • Publication Date: 2015
  • Doi Number: 10.1016/j.bjan.2014.05.006
  • Title of Journal : REVISTA BRASILEIRA DE ANESTESIOLOGIA
  • Page Numbers: pp.191-199

Abstract

Background and objectives: Intraoperative use of opioids may be associated with postoperative hyperalgesia and increased analgesic consumption. Side effects due to perioperative use of opioids, such as postoperative nausea and vomiting may delay discharge. We hypothesized that total intravenous anesthesia consisting of lidocaine and dexmedetomidine as an opioid substitute may be an alternative technique for laparoscopic cholecystectomy and would be associated with lower fentanyl requirements in the postoperative period and less incidence of postoperative nausea and vomiting.