Opioid-free total intravenous anesthesia with propofol, dexmedetomidine and lidocaine infusions for laparoscopic cholecystectomy: a prospective, randomized, double-blinded study

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Bakan M., Umutoglu T., Topuz U., UYSAL H., Bayram M., Kadioglu H., ...More

REVISTA BRASILEIRA DE ANESTESIOLOGIA, vol.65, no.3, pp.191-199, 2015 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 65 Issue: 3
• Publication Date: 2015
• Doi Number: 10.1016/j.bjan.2014.05.006
• Journal Name: REVISTA BRASILEIRA DE ANESTESIOLOGIA
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.191-199
• Istanbul University Affiliated: Yes

Abstract

Background and objectives: Intraoperative use of opioids may be associated with postoperative hyperalgesia and increased analgesic consumption. Side effects due to perioperative use of opioids, such as postoperative nausea and vomiting may delay discharge. We hypothesized that total intravenous anesthesia consisting of lidocaine and dexmedetomidine as an opioid substitute may be an alternative technique for laparoscopic cholecystectomy and would be associated with lower fentanyl requirements in the postoperative period and less incidence of postoperative nausea and vomiting.