Concomitant association of thyroid sarcoidosis and Graves' disease

Yarman S., Kahraman H., Tanakol R., Kapran Y.

HORMONE RESEARCH, cilt.59, sa.1, ss.43-46, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Sayı: 1
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1159/000067937
  • Dergi Adı: HORMONE RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.43-46
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: Graves' disease (GD) with sarcoid involvement of the thyroid gland has rarely been reported. Method. We report a case of GD with thyroid sarcoidosis in a 28-year-old woman. Thyroid function was assessed by triiodothyronine (T-3), thyroxine (T-4), thyroid-stimulating hormone (TSH) and TSH receptor antibodies (TSH-R Ab). Thyroid scintigraphy, ultrasound and fine-needle aspiration biopsy were performed. The patient underwent surgery. Result. The patient had a nodular goiter. Serum T-3, T-4 and TSH-R Ab levels were elevated with suppressed TSH level. Scintigraphy showed diffuse activity as seen in GD, and ultrasound revealed that parenchyma was heterogenous. Sarcoidosis was discovered on routine chest X-ray. Although no sarcoid involvement was found on specimen, the thyroid gland showed noncaseating granulomas on histology. Conclusion: Since sarcoid involvement of the thyroid gland can cause hypofunction, we report the uncommon infiltration of sarcoidosis with hyperthyroidism. Copyright (C) 2003 S. Karger AG, Basel.