Are IVS4 SNPs of OLR1 gene associated with coronary artery disease: Is there a linkage between IVS4 SNPs?
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, cilt.27, ss.321-326, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 27
- Basım Tarihi: 2018
- Doi Numarası: 10.17219/acem/68395
- Dergi Adı: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.321-326
- Anahtar Kelimeler: single nucleotide polymorphism, coronary artery disease, serum lipids, linkage disequilibrium, OLR1 gene, LOW-DENSITY-LIPOPROTEIN, ACUTE MYOCARDIAL-INFARCTION, LECTIN-LIKE, RECEPTOR-1 LOX-1, POLYMORPHISM
- İstanbul Üniversitesi Adresli: Evet
Özet
Background. The OLR1 gene has been identified as a candidate gene for coronary artery disease (CAD). Six single-nucleotide polymorphisms (SNPs) of the OLR1 gene located within intron 4 (IVS4-27G>C, IVS4-73C>T, IVS4-14A>G), intron 5 (IVS5-70A>G, IVS5-27G>T) and 3'UTR (188C>T) comprise a linkage disequilibrium (LD) block, which is strongly associated with the elevated risk of CAD.