Are IVS4 SNPs of OLR1 gene associated with coronary artery disease: Is there a linkage between IVS4 SNPs?

Kurnaz-Gomleksiz O., Kucukhuseyin O., Ozkok E., Bugra Z., Ozturk O., Yilmaz-Aydogan H.

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, vol.27, pp.321-326, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27
  • Publication Date: 2018
  • Doi Number: 10.17219/acem/68395
  • Journal Name: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.321-326
  • Keywords: single nucleotide polymorphism, coronary artery disease, serum lipids, linkage disequilibrium, OLR1 gene, LOW-DENSITY-LIPOPROTEIN, ACUTE MYOCARDIAL-INFARCTION, LECTIN-LIKE, RECEPTOR-1 LOX-1, POLYMORPHISM
  • Istanbul University Affiliated: Yes

Abstract

Background. The OLR1 gene has been identified as a candidate gene for coronary artery disease (CAD). Six single-nucleotide polymorphisms (SNPs) of the OLR1 gene located within intron 4 (IVS4-27G>C, IVS4-73C>T, IVS4-14A>G), intron 5 (IVS5-70A>G, IVS5-27G>T) and 3'UTR (188C>T) comprise a linkage disequilibrium (LD) block, which is strongly associated with the elevated risk of CAD.