Are IVS4 SNPs of OLR1 gene associated with coronary artery disease: Is there a linkage between IVS4 SNPs?

Kurnaz-Gomleksiz O., Kucukhuseyin O. , Ozkok E. , Bugra Z. , Ozturk O. , Yilmaz-Aydogan H.

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, cilt.27, ss.321-326, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 27
  • Basım Tarihi: 2018
  • Doi Numarası: 10.17219/acem/68395
  • Dergi Adı: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
  • Sayfa Sayıları: ss.321-326

Özet

Background. The OLR1 gene has been identified as a candidate gene for coronary artery disease (CAD). Six single-nucleotide polymorphisms (SNPs) of the OLR1 gene located within intron 4 (IVS4-27G>C, IVS4-73C>T, IVS4-14A>G), intron 5 (IVS5-70A>G, IVS5-27G>T) and 3'UTR (188C>T) comprise a linkage disequilibrium (LD) block, which is strongly associated with the elevated risk of CAD.