Assessment of IL-31 levels and disease severity in children with atopic dermatitis.

Ozceker D., Bulut M., Ozbay A. C., Dilek F., Koser M., Tamay Z. Ü., ...More

Allergologia et immunopathologia, vol.46, no.4, pp.322-325, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 4
  • Publication Date: 2018
  • Doi Number: 10.1016/j.aller.2017.10.005
  • Journal Name: Allergologia et immunopathologia
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.322-325
  • Keywords: Atopic dermatitis, Pruritus, Children, Interleukin 31, T-CELLS, INTERLEUKIN-31, EXPRESSION, CORRELATE, PRURITUS, ITCH
  • Istanbul University Affiliated: Yes

Abstract

Introduction and objectives: Atopic dermatitis is a chronic, relapsing, highly pruritic, inflam- matory skin disease characterized by typical localization with increasing prevalence of 10-20% in children. Pruritus is one of the major diagnostic criteria of atopic dermatitis and also the main complaint altering quality-of-life of affected patients, inducing and aggravating inflammation. Although pruritus is the absolute symptom of AD, the etiology has not been fully explained yet and current antihistamine therapies are ineffective.