Background:In an older population, insertion of peripheral intravenous catheterizations (PIVCs) are more difficult because of specific problems. Aim:This study aimed to determine the initial efficacy of non-tourniquet procedure during insertion of PIVC in older patients. Design/Methods:This quasi-experimental study was conducted in 78 older patients. The initial efficacy of non-tourniquet procedure was tested during insertion of PIVC. Results:This study showed that similar pain intensity scores immediately after inserting the PIVC (p>0.05). The first-attempt success and dwell time in non-tourniquet procedure older patients were be higher/longer and phlebitis scores were lower than the control group (p<0.05). Conclusions:To increase the success of PIVC first-attempt, a longer dwell time, and lower phlebitis scores in older patients, nurses should insert PIVCs at an almost flat degree and stabilize the vein without a tourniquet. Impact statement:The non-tourniquet procedure will lead to the long dwell time and using safely of PIVC in older patients.