Akademik Veri Yönetim Sistemi
Sirkadiyen Düzenleme Metotlar ve Protokoller, Guiomar Solanas,Patrick -Simon Welz, Editör, Springer Nature, New York, ss.15-34, 2022
Circadian rhythms are part of the body’s clock, which regulates several physiological and biochemical variables according to the 24-h cycle. Ample evidence indicated disturbance of the circadian clock leads to an increased susceptibility to several diseases. Therefore, a great effort has been made to find small molecules that regulate circadian rhythm by high-throughput methods. Having crystal structures of core clock proteins, makes them amenable to structure-based drug design studies. Here, we describe virtual screening methods that can be utilized for the identification of small molecules regulating the activity of core clock protein Cryptochrome 1.