Oxidative damage to nuclear DNA in streptozotocin-diabetic rat liver

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Atıf İçin Kopyala

Andican G., Burcak G.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, cilt.32, sa.8, ss.663-666, 2005 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 32 Sayı: 8
• Basım Tarihi: 2005
• Doi Numarası: 10.1111/j.0305-1870.2005.04247.x
• Dergi Adı: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.663-666
• İstanbul Üniversitesi Adresli: Evet

Özet

1. Accumulating evidence suggests that oxidative and glycative stress is enhanced in diabetes. Oxidative stress induces DNA damage. In the present study, we assessed the 8-oxo-2'-deoxyguanosine (8-oxodG) content of DNA, an indicator of oxidative DNA damage, in streptozotocin (STZ)-induced diabetic (n=21) and control rats (n=18).