Oxidative damage to nuclear DNA in streptozotocin-diabetic rat liver


Andican G., Burcak G.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, vol.32, no.8, pp.663-666, 2005 (SCI-Expanded) identifier identifier identifier

Abstract

1. Accumulating evidence suggests that oxidative and glycative stress is enhanced in diabetes. Oxidative stress induces DNA damage. In the present study, we assessed the 8-oxo-2'-deoxyguanosine (8-oxodG) content of DNA, an indicator of oxidative DNA damage, in streptozotocin (STZ)-induced diabetic (n=21) and control rats (n=18).