Comparison of biological stability and metabolism of CCK2 receptor targeting peptides, a collaborative project under COST BM0607

Ocak M., Helbok A., Rangger C., Peitl P. K., Nock B. A., Morelli G., ...More

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, vol.38, no.8, pp.1426-1435, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 8
  • Publication Date: 2011
  • Doi Number: 10.1007/s00259-011-1818-9
  • Journal Name: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1426-1435
  • Keywords: Cholecystokinin receptor, (177)Lu, Gastrin, CCK, In vitro stability, In vivo stability, Metabolism, INITIAL CLINICAL-EVALUATION, IN-VIVO EVALUATION, RADIOLABELED PEPTIDES, RADIONUCLIDE THERAPY, THYROID-CANCER, GASTRIN, ANALOGS, RADIOPHARMACEUTICALS, TUMORS, STRATEGIES
  • Istanbul University Affiliated: Yes

Abstract

Stability of radiolabelled cholecystokinin 2 (CCK2) receptor targeting peptides has been a major limitation in the use of such radiopharmaceuticals especially for targeted radionuclide therapy applications, e.g. for treatment of medullary thyroid carcinoma (MTC). The purpose of this study was to compare the in vitro stability of a series of peptides binding to the CCK2 receptor [selected as part of the COST Action on Targeted Radionuclide Therapy (BM0607)] and to identify major cleavage sites.