Comparison of biological stability and metabolism of CCK2 receptor targeting peptides, a collaborative project under COST BM0607

Ocak M., Helbok A., Rangger C., Peitl P. K., Nock B. A., Morelli G., ...Daha Fazla

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, cilt.38, sa.8, ss.1426-1435, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 8
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1007/s00259-011-1818-9
  • Dergi Adı: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1426-1435
  • Anahtar Kelimeler: Cholecystokinin receptor, (177)Lu, Gastrin, CCK, In vitro stability, In vivo stability, Metabolism, INITIAL CLINICAL-EVALUATION, IN-VIVO EVALUATION, RADIOLABELED PEPTIDES, RADIONUCLIDE THERAPY, THYROID-CANCER, GASTRIN, ANALOGS, RADIOPHARMACEUTICALS, TUMORS, STRATEGIES
  • İstanbul Üniversitesi Adresli: Evet

Özet

Stability of radiolabelled cholecystokinin 2 (CCK2) receptor targeting peptides has been a major limitation in the use of such radiopharmaceuticals especially for targeted radionuclide therapy applications, e.g. for treatment of medullary thyroid carcinoma (MTC). The purpose of this study was to compare the in vitro stability of a series of peptides binding to the CCK2 receptor [selected as part of the COST Action on Targeted Radionuclide Therapy (BM0607)] and to identify major cleavage sites.