The association of P-selectin glycoprotein ligand-1 VNTR polymorphisms with coronary stent restenosis


Ozben B., Diz-Kucukkaya R., Bilge A. K. , Hancer V. S. , Oncul A.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS, vol.23, no.3, pp.181-187, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 3
  • Publication Date: 2007
  • Doi Number: 10.1007/s11239-006-9020-9
  • Title of Journal : JOURNAL OF THROMBOSIS AND THROMBOLYSIS
  • Page Numbers: pp.181-187

Abstract

Background P-selectin and P-selectin glycoprotein ligand-1 (PSGL-1) regulate the initial interactions between leukocytes, activated platelets and endothelial cells. Recently, a variable number of tandem repeats (VNTR) polymorphism in PSGL-1 gene affecting the length of the extracellular domain of PSGL-1 and the distance of the P-selectin binding site to the cell surface has been described. There are limited numbers of studies reporting PSGL-1 polymorphism might affect the inflammatory response and thrombosis. We explored the association between PSGL-1 VNTR polymorphisms (especially AB genotype that has the most deformed configuration of the binding site) and the development of coronary stent restenosis and stent thrombosis in patients with coronary artery disease (CAD).