Protective effect of dexpanthenol against nephrotoxic effect of amikacin: An experimental study

Dogan E. E., Erkoc R., Ekinci I., Hamdard J., Doner B., Cikrikcioglu M. A., ...More

BIOMEDICINE & PHARMACOTHERAPY, vol.89, pp.1409-1414, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 89
  • Publication Date: 2017
  • Doi Number: 10.1016/j.biopha.2017.03.019
  • Journal Name: BIOMEDICINE & PHARMACOTHERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1409-1414
  • Keywords: Amikacin, Dexpanthenol, Nephrotoxicity, Oxidative stress, PANTOTHENIC-ACID, GLUTATHIONE, EXTRACT, INJURY, DAMAGE
  • Istanbul University Affiliated: No

Abstract

Background: Amikacin has the largest spectrum among aminoglycosides, its nephrotoxic effect limits its utilization. Our purpose in this study is to review the protective effect of dexpanthenol against the nephrotoxic effect of amikacin, accompanied with histopathological and biochemical parameters.