Angiotensin-converting enzyme I/D gene polymorphisms and effects of left ventricular hypertrophy in Turkish myocardial infarction patients
ACTA CARDIOLOGICA, vol.59, no.5, pp.493-497, 2004 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 59 Issue: 5
- Publication Date: 2004
- Doi Number: 10.2143/ac.59.5.2005221
- Journal Name: ACTA CARDIOLOGICA
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.493-497
- Keywords: angiotensin-converting enzyme polymorphism, left ventricular hypertrophy, myocardial infarction, CORONARY-ARTERY-DISEASE, IDIOPATHIC DILATED CARDIOMYOPATHY, INSERTION DELETION POLYMORPHISM, DEPENDENT DIABETES-MELLITUS, ISCHEMIC-HEART-DISEASE, INCREASED RISK, ASSOCIATION, LOCUS, HYPERTENSION, POPULATIONS
- Istanbul University Affiliated: Yes
Abstract
Objective - Since the initial report of the association of the deletion/insertion (D/I) polymorphism in the gene for angiotensin-converting enzyme (ACE) with myocardial infarction (MI), there has been considerable controversy. Some have found the D allele to be associated with MI, coronary heart disease (CHD) or other cardiac pathologies, while others have not. In view of the clinical importance of the ACE as a major marker of cardiovascular diseases, we investigated the I/D polymorphism of the ACE gene in Turkish patients with acute myocardial infarction in comparison with control subjects.