Akademik Veri Yönetim Sistemi
Journal of Drug Delivery Science and Technology, cilt.122, 2026 (SCI-Expanded, Scopus)
Based on extensive literature and clinical evidence, doxorubicin (DOX) remains one of the most widely used chemotherapeutic agents; however, its clinical application is significantly constrained by dose-dependent systemic toxicity, limited tumor selectivity, and the emergence of multidrug resistance. Advances in nanotechnology have led to the development of stimuli-responsive nanocarrier systems and sophisticated drug delivery platforms capable of enabling site-specific and controlled release of doxorubicin, thereby establishing new research directions and attracting increasing scientific interest. This review systematically summarizes and critically evaluates studies published over the past five years that focus on stimuli-responsive drug delivery systems employing doxorubicin as a therapeutic cargo. The platforms discussed include pH-, redox-, enzyme-, reactive oxygen species-, hypoxia-, and temperature-responsive systems, as well as externally triggered approaches such as light, magnetic field, and ultrasound-mediated release, with particular emphasis on their design strategies, release mechanisms, and therapeutic performance. Overall, this review provides a consolidated framework for the rational design of next-generation responsive nanocarriers aimed at enhancing the therapeutic index of doxorubicin and facilitating its clinical translation.