Vascular endothelial growth factor gene polymorphisms in Turkish patients with sarcoidosis


SEYHAN E. C. , CETINKAYA E., ALTIN S., GUNLUOGLU M. Z. , DEMIR A., KOKSAL V., ...More

TISSUE ANTIGENS, vol.72, pp.162-165, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 72 Issue: 2
  • Publication Date: 2008
  • Doi Number: 10.1111/j.1399-0039.2008.01076.x
  • Title of Journal : TISSUE ANTIGENS
  • Page Numbers: pp.162-165

Abstract

Polymorphism at +813 locus of vascular endothelial growth factor (VEGF) gene is considered to decrease predisposition to sarcoidosis. Our study aimed to investigate the roles of this polymorphism in the development and extent of sarcoidosis. We examined polymorphisms of the VEGF gene in 90 cases with histopathological diagnosis of sarcoidosis and in 110 healthy subjects. VEGF +813 gene polymorphisms were determined using a polymerase chain reaction-based method after DNA isolation. A significant increase in the frequency of the T allele was found in healthy subjects (odds ratio 0.55; 95% confidence interval 0.32-0.97, P < 0.05). Our results suggest that increase in rarer T allele at + 813 locus of VEGF gene may diminish susceptibility to sarcoidosis in Turkish population.