Vascular endothelial growth factor gene polymorphisms in Turkish patients with sarcoidosis

SEYHAN E. C., CETINKAYA E., ALTIN S., GUNLUOGLU M. Z., DEMIR A., KOKSAL V., ...Daha Fazla

TISSUE ANTIGENS, sa.2, ss.162-165, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1111/j.1399-0039.2008.01076.x
  • Dergi Adı: TISSUE ANTIGENS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.162-165
  • İstanbul Üniversitesi Adresli: Evet

Özet

Polymorphism at +813 locus of vascular endothelial growth factor (VEGF) gene is considered to decrease predisposition to sarcoidosis. Our study aimed to investigate the roles of this polymorphism in the development and extent of sarcoidosis. We examined polymorphisms of the VEGF gene in 90 cases with histopathological diagnosis of sarcoidosis and in 110 healthy subjects. VEGF +813 gene polymorphisms were determined using a polymerase chain reaction-based method after DNA isolation. A significant increase in the frequency of the T allele was found in healthy subjects (odds ratio 0.55; 95% confidence interval 0.32-0.97, P < 0.05). Our results suggest that increase in rarer T allele at + 813 locus of VEGF gene may diminish susceptibility to sarcoidosis in Turkish population.