Synthesis and antitubercular activity of 4-(3-coumarinyl)-3-cyclohexyl-4-thiazolin-2-one benzylidenehydrazones


Karali N. L. , Kocabalkanli A., Gursoy A., Ates O.

FARMACO, vol.57, no.7, pp.589-593, 2002 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 7
  • Publication Date: 2002
  • Doi Number: 10.1016/s0014-827x(02)01254-5
  • Title of Journal : FARMACO
  • Page Numbers: pp.589-593
  • Keywords: coumarins, thiazolines, benzylidene hydrazones, antitubercular activity, DERIVATIVES

Abstract

In this study, a new series of 4-(3-coumarinyl)-3-cyclohexyl-4-thiazoline-2-one benzylidene hydrazones (3a-p) were synthesized. Structures of the title compounds were determined by analytical and spectral methods. 3a-p were evaluated for antituberculosis activity against Mycobacterium tuberculosis H37Rv. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.