Frequency of Rearrangements Versus Small Indels Mutations in BRCA1 and BRCA2 Genes in Turkish Patients with High Risk Breast and Ovarian Cancer


Yazici H. , Kilic S., Akdeniz D. , Sukruoglu Ö. , Tuncer S. B. , Avsar M., ...More

EUROPEAN JOURNAL OF BREAST HEALTH, vol.14, pp.93-99, 2018 (Journal Indexed in ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.5152/ejbh.2017.3799
  • Title of Journal : EUROPEAN JOURNAL OF BREAST HEALTH
  • Page Numbers: pp.93-99

Abstract

Objective: The current rearrangement ratio of BRCA1 and BRCA2 genes is not known in the Turkish population. Rearrangements are not routinely investigated in many Turkish laboratories. This creates problems and contradictions between clinics. Therefore, the aim of this study was to evaluate the distribution and frequency of rearrangements in BRCA1 and BRCA2 genes in high-risk families and to clarify the limits of BRCA1 and BRCA2 testing in Turkey.