Nitrated nucleosome levels and neuropsychiatric events in systemic lupus erythematosus; a multi-center retrospective case-control study.

Ferreira I., Croca S., Raimondo M. G., Matharu M., Miller S., Giles I., ...Daha Fazla

Arthritis research & therapy, cilt.19, sa.1, ss.287, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1186/s13075-017-1495-6
  • Dergi Adı: Arthritis research & therapy
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.287
  • Anahtar Kelimeler: Systemic lupus erythematosus, Neuropsychiatric, Nucleosomes, Nitration, NITRIC-OXIDE SYNTHASE, DISEASE, HEADACHE, SERUM, DIAGNOSIS, PLASMA, BRAIN, SLE
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: In patients with systemic lupus erythematosus (SLE) there is no serological test that will reliably distinguish neuropsychiatric (NP) events due to active SLE from those due to other causes. Previously we showed that serum levels of nitrated nucleosomes (NN) were elevated in a small number of patients with NPSLE. Here we measured serum NN in samples from a larger population of patients with SLE and NP events to see whether elevated serum NN could be a marker for NPSLE.