Inhibitory effect of Hesperidin on tumour initiation and promotion in mouse skin


Berkarda B., Koyuncu H., Soybir G., Baykut F.

RESEARCH IN EXPERIMENTAL MEDICINE, vol.198, no.2, pp.93-99, 1998 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 198 Issue: 2
  • Publication Date: 1998
  • Doi Number: 10.1007/s004330050093
  • Journal Name: RESEARCH IN EXPERIMENTAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.93-99
  • Istanbul University Affiliated: No

Abstract

A flavonoid, Hesperidin was evaluated for its ability to inhibit tumour initiation by a polycyclic aromatic hydrocarbon and tumour promotion by a phorbol ester in the skin of CD-1 mice. Subcutaneous application of Hesperidin did not inhibit 7,12-dimethylbenz(a)anthracene-induced tumour initiation but did inhibit 12-O-tetradecanoyl-13-phorbol acetate-induced tumour promotion. Results provide evidence for a potential chemopreventive activity of Hesperidin.