Review for Disease of the Year: Varicella Zoster Virus-Induced Anterior Uveitis


Tugal-Tutkun I. , Cimino L., Akova Y. A.

OCULAR IMMUNOLOGY AND INFLAMMATION, cilt.26, ss.171-177, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 26 Konu: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1080/09273948.2017.1383447
  • Dergi Adı: OCULAR IMMUNOLOGY AND INFLAMMATION
  • Sayfa Sayıları: ss.171-177

Özet

Varicella zoster virus (VZV)-induced anterior uveitis (AU) may complicate the course of primary varicella infection typically seen in children. In adults, especially with advanced age, VZV AU is more commonly associated with herpes zoster ophthalmicus (HZO) with or without skin rash affecting the distribution of the ophthalmic nerve due to reactivation of the latent VZV in the trigeminal ganglion. While it is typically a mild self-limiting AU in primary infection, HZO AU is often accompanied by keratitis, may have a chronic recurrent course, and lead to sectoral iris atrophy, pupillary distortion, and ocular hypertension. Diagnosis is often clinical and proven by analysis of aqueous humor for viral genome or antiviral antibodies. Systemic antiviral agents and topical steroids are the mainstay of treatment. Visual prognosis is favorable with timely diagnosis and appropriate treatment.