Modulating the functions of neutrophils and lipid peroxidation by FK506 in a rat model of thermal injury

Cetinkale O., Konukoglu D., Senel O., Kemerli G., Yazar S.

BURNS, vol.25, no.2, pp.105-112, 1999 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 2
  • Publication Date: 1999
  • Doi Number: 10.1016/s0305-4179(98)00147-8
  • Journal Name: BURNS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.105-112
  • Istanbul University Affiliated: No


Neutrophils diffusely invade lung, liver, kidney, intestine, muscle and burned skin following burn injury. To ameliorate this invasion and minimize its effects, neutrophils can be modulated by giving neutrophil inhibitors and modulators. In this study, FK506 was used to decrease neutrophil infiltration and lipid peroxidation in remote organs (lung, liver, kidney and intestine) in a burned rat model.