Acute hepatitis B despite a previous high titer of anti-HBs

Ozaras R. , Ar C., Ongoren S., Mete B. , Tabak F. , Mert A., ...Daha Fazla

HEPATOLOGY INTERNATIONAL, cilt.4, ss.530-532, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 4 Konu: 2
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1007/s12072-010-9177-3
  • Sayfa Sayıları: ss.530-532


Loss of HBsAg and development of surface and core antibodies represent clinical cure. However, recent evidence suggests that hepatitis B virus (HBV) persists in a latent state even in those with mounted protective antibodies. After significant immunosuppression, anti-HBs may decrease and HBsAg may reappear (reverse seroconversion). Reverse seroconversion of HBV has been observed in association with hematopoietic stem cell transplantation, renal transplantation, intensive chemotherapy, human immunodeficiency infection, or rituximab usage.