THE EFFICACY OF A 5-DRUG ANTIEMETIC COMBINATION DURING CHEMOTHERAPY REGIMENS CONTAINING CISPLATIN OR CYCLOPHOSPHAMIDE DOXORUBICIN

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AYDINER A., ONAT H., OZTURK N., AYKAN F., INANC S., TOPUZ E., ...More

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, vol.8, no.3, pp.126-131, 1993 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 8 Issue: 3
• Publication Date: 1993
• Doi Number: 10.1016/0885-3924(93)90140-q
• Journal Name: JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.126-131
• Istanbul University Affiliated: Yes

Abstract

A five-drug combination, including metoclopramide, thiethylperazine, diphenhydramine, dexamethasone, and diazepam, was given to 32 patients during three consecutive treatments with chemotherapy. Eighteen patients (group A) were treated with a cisplatin-containing regimen, and 14 patients (group B) were treated with a cyclophosphamide- and doxorubicin-containing chemotherapy. In group A, complete responses were lower on the first day than on the second and third days (P < 0.015 and P < 0.041, respectively), during the first and second courses. The five-drug antiemetic regimen seems safe and effective. These results show that clinical trials that evaluate antiemetic efficacy in cisplatin-containing chemotherapy regimens should evaluate at least two consecutive courses.