Utility of 68 Ga-FAPI-04 PET/CT in Adenoid Cystic Carcinoma Compared With 18 F-FDG PET/CT : Two Case Reports.

Civan C., Isik E. G., Has Simsek D., Buyukkaya F., Kuyumcu S.

Clinical nuclear medicine, cilt.48, sa.7, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48 Sayı: 7
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1097/rlu.0000000000004687
  • Dergi Adı: Clinical nuclear medicine
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
  • Anahtar Kelimeler: 18F-FDG, 68Ga-FAPI, adenoid cystic carcinoma, CAF, FAPI, PET/CT
  • İstanbul Üniversitesi Adresli: Evet

Özet

68Ga-fibroblast activation protein inhibitor (FAPI) PET/CT is an emerging imaging modality with high sensitivity and high tumor-to-background ratio in various cancers including in the head and neck regions. The authors present 2 cases of adenoid cystic carcinoma who underwent 68Ga-FAPI-04 and 18F-FDG PET/CT. Locoregional recurrence has been detected more precisely in the first case with 68Ga-FAPI-04. In the second case, 68Ga-FAPI-04 outperformed 18F-FDG in the number of lesions and demonstrated intense FAP uptake on widespread metastases, which could provide a treatment option as a theranostic concept. These cases highlight that 68Ga-FAPI-04 PET/CT may be useful for detecting local recurrence and metastases and help select patients for radionuclide treatments targeting cancer-associated fibroblasts.