Effects of Atorvastatin on Vascular Intimal Hyperplasia: An Experimental Rodent Model

Aydin U., Ugurlucan M., GUNGOR F., ZİYADE S., İNAN B., BANACH M., ...More

ANGIOLOGY, vol.60, no.3, pp.370-377, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 60 Issue: 3
  • Publication Date: 2009
  • Doi Number: 10.1177/0003319708321102
  • Journal Name: ANGIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.370-377
  • Istanbul University Affiliated: Yes


Introduction Vascular intimal hyperplasia is associated with increased mortality and morbidity. The authors investigated the effects of atorvastatin on vascular intimal hyperplasia. Materials and methods Rats were divided into 4 groups. Groups 1, 2, and 3 had experimental aortic injury and received intraperitoneal injection of atorvastatin, solvent, or 0.9% NaCl, respectively. Group 4 was a nonintervention (laparotomy only) control group. Animals were sacrificed after 3 weeks. Blood samples and injured aortic segment were analyzed. Results Atorvastatin administration significantly lowered total and low-density lipoprotein cholesterol levels (P=.012 and P=.001, respectively) intima-media ratio (P=.002), and intimal smooth muscle Cell accumulation (P<.05) in group 1. Luminal narrowing in animals in group 1 was significantly lower than that in animals in groups 2 and 3, but was higher than in animals in group 4 (P=.009). Conclusions Atorvastatin suppresses intimal hyerplasia and aids in intimal regeneration by lowering blood lipids and intimal smooth Muscle Cell accumulation.