Sodium fusidate-poly(D,L-lactide-co-glycolide) microspheres: Preparation, characterisation and in vivo evaluation of their effectiveness in the treatment of chronic osteomyelitis
JOURNAL OF MICROENCAPSULATION, cilt.24, sa.6, ss.577-595, 2007 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 24 Sayı: 6
- Basım Tarihi: 2007
- Doi Numarası: 10.1080/02652040701472584
- Dergi Adı: JOURNAL OF MICROENCAPSULATION
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.577-595
- Anahtar Kelimeler: sodium fusidate, poly(D,L-lactide-co-glycolide) microspheres, emulsion solvent evaporation method, methicillin-resistant Staphylococcus aureus, chronic osteomyelitis, RESISTANT STAPHYLOCOCCUS-AUREUS, CIPROFLOXACIN IMPLANTS, BONE IMPLANTATION, FUSIDIC ACID, LACTIC-ACID, VITRO, MICROPARTICLES, FORMULATION, VANCOMYCIN, SIZE
- İstanbul Üniversitesi Adresli: Evet
Özet
Purpose: The aim of this study was to prepare poly(D, L- lactide-co-glycolide) (PLGA) microspheres containing sodium fusidate ( SF) using a double emulsion solvent evaporation method with varying polymer: drug ratios (1: 1, 2.5: 1, 5: 1) and to evaluate its efficiency for the local treatment of chronic osteomyelitis.