Sodium fusidate-poly(D,L-lactide-co-glycolide) microspheres: Preparation, characterisation and in vivo evaluation of their effectiveness in the treatment of chronic osteomyelitis

Cevher E., Orhan Z., Şensoy D., Ahıskalı R., Kan P. L., Sağırlı O., ...More

JOURNAL OF MICROENCAPSULATION, vol.24, no.6, pp.577-595, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 6
  • Publication Date: 2007
  • Doi Number: 10.1080/02652040701472584
  • Journal Name: JOURNAL OF MICROENCAPSULATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.577-595
  • Keywords: sodium fusidate, poly(D,L-lactide-co-glycolide) microspheres, emulsion solvent evaporation method, methicillin-resistant Staphylococcus aureus, chronic osteomyelitis, RESISTANT STAPHYLOCOCCUS-AUREUS, CIPROFLOXACIN IMPLANTS, BONE IMPLANTATION, FUSIDIC ACID, LACTIC-ACID, VITRO, MICROPARTICLES, FORMULATION, VANCOMYCIN, SIZE
  • Istanbul University Affiliated: Yes

Abstract

Purpose: The aim of this study was to prepare poly(D, L- lactide-co-glycolide) (PLGA) microspheres containing sodium fusidate ( SF) using a double emulsion solvent evaporation method with varying polymer: drug ratios (1: 1, 2.5: 1, 5: 1) and to evaluate its efficiency for the local treatment of chronic osteomyelitis.