Akademik Veri Yönetim Sistemi
Society of hematologic oncology, İstanbul, Türkiye, 5 - 07 Mayıs 2023, ss.33
Objective The effect of amino acid sequences in mismatched HLA patient-donor pairs on the clinical picture after hematopoietic stem cell transplantation (HSCT) is not clear yet. In this regard to understand the epitopes recognized by the immune system, databases have been created. We investigated the effect of the HLA mismatch on HSCT outcome.
Case Report Methodology Between 2011 – 2021, 22 patient and donor pairs enrolled in the study. Sequencing-based typing and the STR method were used for HLA groupings and chimerism analyses, respectively. For epitope analyses, the HLA epitope registry was used. Donors were 9/10 matched unrelated. Most of the mismatch was in HLA A group in 13 patients followed by 4 patients in HLA B and HLA DR in 3 patients.
Results Eleven patients had 0-5 epitope mismatch, 4 of them developed GVHD, and 5 survived. Five patients had 6 -15 epitope mismatch, 4 of them developed GVHD, and 1 survived. In 6 patients epitope mismatch was greater than 16. Five of them developed GVHD and 4 survived. The relapse rate was not statistically significant among all groups. The frequency of patients with one allele but 0-5 epitope mismatch was approximately one-half lower which was statistically not significant.
Conclusion We think epitope matching might be useful for identifying patients who are at
high risk for serious complications such as GVHD after HSCT in HLA mismatched unrelated
donors