Efficacy and tolerability of fixed, low-dose combination therapy with verapamil sustained-release and trandolapril in patients with mild to severe essential hypertension uncontrolled by monotherapy: An open-label, multicenter trial

Adalet, Kamil; Oflaz, H; Sezer, A; Buyukozturk, K

doi:10.1016/s0011-393x(01)80010-2

Efficacy and tolerability of fixed, low-dose combination therapy with verapamil sustained-release and trandolapril in patients with mild to severe essential hypertension uncontrolled by monotherapy: An open-label, multicenter trial

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Adalet K., Oflaz H., Sezer A., Buyukozturk K.

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, vol.62, no.4, pp.261-271, 2001 (SCI-Expanded)

Publication Type: Article / Article
Volume: 62 Issue: 4
Publication Date: 2001
Doi Number: 10.1016/s0011-393x(01)80010-2
Journal Name: CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.261-271
Istanbul University Affiliated: Yes

Abstract

Background: Only 40% to 60% of patients with essential hypertension respond adequately to antihypertensive monotherapy. The combination of an angiotensin-converting enzyme inhibitor and a calcium antagonist, both of which have tissue-protective properties but different mechanisms of action, may lead to an additive antihypertensive effect.