Efficacy and tolerability of fixed, low-dose combination therapy with verapamil sustained-release and trandolapril in patients with mild to severe essential hypertension uncontrolled by monotherapy: An open-label, multicenter trial


Adalet K., Oflaz H., Sezer A., Buyukozturk K.

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, cilt.62, ss.261-271, 2001 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 62 Konu: 4
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1016/s0011-393x(01)80010-2
  • Dergi Adı: CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL
  • Sayfa Sayıları: ss.261-271

Özet

Background: Only 40% to 60% of patients with essential hypertension respond adequately to antihypertensive monotherapy. The combination of an angiotensin-converting enzyme inhibitor and a calcium antagonist, both of which have tissue-protective properties but different mechanisms of action, may lead to an additive antihypertensive effect.