Efficacy and tolerability of fixed, low-dose combination therapy with verapamil sustained-release and trandolapril in patients with mild to severe essential hypertension uncontrolled by monotherapy: An open-label, multicenter trial

Adalet K., Oflaz H., Sezer A., Buyukozturk K.

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, vol.62, no.4, pp.261-271, 2001 (SCI-Expanded) identifier identifier


Background: Only 40% to 60% of patients with essential hypertension respond adequately to antihypertensive monotherapy. The combination of an angiotensin-converting enzyme inhibitor and a calcium antagonist, both of which have tissue-protective properties but different mechanisms of action, may lead to an additive antihypertensive effect.