Protein Expression in the Diagnosis of LRBA Deficiency by Flow Cytometer

ÖĞÜLÜR İ., Kiykim A., NAIN E., Somer A., Guven A., BARIŞ S., ...More

ASTIM ALLERJI IMMUNOLOJI, vol.15, no.3, pp.123-128, 2017 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.21911/aai.368
  • Journal Name: ASTIM ALLERJI IMMUNOLOJI
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.123-128
  • Istanbul University Affiliated: Yes

Abstract

Objective: Lipopolysaccharide-responsive beige-like anchor (LRBA) plays a role in cell surface expression of inhibitory cytotoxic T lymphocyte-associated protein-4 (CTLA-4) protein. Recently identified LRBA deficiency leads to immune deficiency and autoimmunity and is diagnosed by mutation analyses and protein expression. Herein, we quantified stimulated and unstimulated intracellular LRBA protein expression by flow cytometry in LRBA deficiency patients.