Protein Expression in the Diagnosis of LRBA Deficiency by Flow Cytometer


ÖĞÜLÜR İ., Kiykim A., NAIN E., Somer A. , Guven A. , BARIŞ S., ...More

ASTIM ALLERJI IMMUNOLOJI, vol.15, pp.123-128, 2017 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.21911/aai.368
  • Title of Journal : ASTIM ALLERJI IMMUNOLOJI
  • Page Numbers: pp.123-128

Abstract

Objective: Lipopolysaccharide-responsive beige-like anchor (LRBA) plays a role in cell surface expression of inhibitory cytotoxic T lymphocyte-associated protein-4 (CTLA-4) protein. Recently identified LRBA deficiency leads to immune deficiency and autoimmunity and is diagnosed by mutation analyses and protein expression. Herein, we quantified stimulated and unstimulated intracellular LRBA protein expression by flow cytometry in LRBA deficiency patients.