Protein Expression in the Diagnosis of LRBA Deficiency by Flow Cytometer

ÖĞÜLÜR İ., Kiykim A., NAIN E., Somer A., Guven A., BARIŞ S., ...Daha Fazla

ASTIM ALLERJI IMMUNOLOJI, cilt.15, sa.3, ss.123-128, 2017 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.21911/aai.368
  • Dergi Adı: ASTIM ALLERJI IMMUNOLOJI
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.123-128
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: Lipopolysaccharide-responsive beige-like anchor (LRBA) plays a role in cell surface expression of inhibitory cytotoxic T lymphocyte-associated protein-4 (CTLA-4) protein. Recently identified LRBA deficiency leads to immune deficiency and autoimmunity and is diagnosed by mutation analyses and protein expression. Herein, we quantified stimulated and unstimulated intracellular LRBA protein expression by flow cytometry in LRBA deficiency patients.