In search of pulmonary hypertension treatments: Effect of 17 beta-estradiol on PGI(2) pathway in human pulmonary artery

Amgoud, Yasmine; Senbel, Amira; Bouhadoun, Amel; Abdelazeem, Heba; Ozen, Gülsev; Savane, Ines; Manikpurage, Hasanga; Mani, Salma; Tran-Dinh, Alexy; Castier, Yves; Guyard, Alice; Longrois, Gökce; Silverstein, Adam; Norel, Xavier

doi:10.1016/j.plefa.2021.102321

In search of pulmonary hypertension treatments: Effect of 17 beta-estradiol on PGI(2) pathway in human pulmonary artery

Atıf İçin Kopyala

Amgoud Y., Senbel A., Bouhadoun A., Abdelazeem H., Ozen G., Savane I., ...Daha Fazla

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, cilt.172, 2021 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 172
Basım Tarihi: 2021
Doi Numarası: 10.1016/j.plefa.2021.102321
Dergi Adı: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
Anahtar Kelimeler: Pulmonary hypertension, PGI(2), 17 beta-estradiol, Human pulmonary artery, Human pulmonary artery smooth muscle cells, PROSTACYCLIN PRODUCTION, ESTRADIOL, ESTROGEN, RECEPTOR, CYCLOOXYGENASE-1, EXPRESSION, CELLS, PROGESTERONE, UTERINE, PGIS
İstanbul Üniversitesi Adresli: Evet

Özet

Introduction: Prostacyclin (PGI(2)) is synthetized by PGI(2) synthase (PGIS) and induces vasorelaxation via activation of cyclic AMP (cAMP) generating IP-receptor. Several components of the PGI(2) signaling pathway are reduced in patients with pulmonary hypertension (PH).