In search of pulmonary hypertension treatments: Effect of 17 beta-estradiol on PGI(2) pathway in human pulmonary artery

Amgoud, Yasmine; Senbel, Amira; Bouhadoun, Amel; Abdelazeem, Heba; Ozen, Gülsev; Savane, Ines; Manikpurage, Hasanga; Mani, Salma; Tran-Dinh, Alexy; Castier, Yves; Guyard, Alice; Longrois, Gökce; Silverstein, Adam; Norel, Xavier

doi:10.1016/j.plefa.2021.102321

In search of pulmonary hypertension treatments: Effect of 17 beta-estradiol on PGI(2) pathway in human pulmonary artery

Amgoud Y., Senbel A., Bouhadoun A., Abdelazeem H., Ozen G., Savane I., ...More

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, vol.172, 2021 (SCI-Expanded)

Publication Type: Article / Article
Volume: 172
Publication Date: 2021
Doi Number: 10.1016/j.plefa.2021.102321
Journal Name: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
Keywords: Pulmonary hypertension, PGI(2), 17 beta-estradiol, Human pulmonary artery, Human pulmonary artery smooth muscle cells, PROSTACYCLIN PRODUCTION, ESTRADIOL, ESTROGEN, RECEPTOR, CYCLOOXYGENASE-1, EXPRESSION, CELLS, PROGESTERONE, UTERINE, PGIS
Istanbul University Affiliated: Yes

Abstract

Introduction: Prostacyclin (PGI(2)) is synthetized by PGI(2) synthase (PGIS) and induces vasorelaxation via activation of cyclic AMP (cAMP) generating IP-receptor. Several components of the PGI(2) signaling pathway are reduced in patients with pulmonary hypertension (PH).