Circulating vaspin levels and epicardial adipose tissue thickness are associated with impaired coronary flow reserve in patients with nonalcoholic fatty liver disease
ATHEROSCLEROSIS, vol.217, no.1, pp.125-129, 2011 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 217 Issue: 1
- Publication Date: 2011
- Doi Number: 10.1016/j.atherosclerosis.2011.03.026
- Journal Name: ATHEROSCLEROSIS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.125-129
- Istanbul University Affiliated: Yes
Abstract
Background: Patients with nonalcoholic fatty liver disease (NAFLD) have a reduced coronary flow reserve (CFR) and an increased risk of cardiovascular disease. The fat cells that surround coronary arteries may play a central and underrecognized role in development of cardiovascular disease through the systemic secretion of adipokines. We therefore evaluated the relation of epicardial fat thickness, serum levels of epicardial fat-related adipokines (chemerin and vaspin), and CFR in patients with NAFLD.