Effectiveness of CoronaVac vaccination against COVID-19 development in healthcare workers: real-life data

Copur B., Surme S., SAYILI U., Tuncer G., Pehlivanoglu F., Sengoz G.

FUTURE MICROBIOLOGY, vol.17, no.17, pp.1381-1391, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 17
  • Publication Date: 2022
  • Doi Number: 10.2217/fmb-2022-0134
  • Journal Name: FUTURE MICROBIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.1381-1391
  • Keywords: CoronaVac effectiveness, COVID-19, healthcare workers, vaccine
  • Istanbul University Affiliated: No

Abstract

Background: This study was designed to investigate the effectiveness of CoronaVac in preventing COVID-19 in healthcare workers (HCWs) during the Alpha variant-dominant period. Materials & methods: Follow-up was initiated 14 days after the second dose for double-dose vaccinated HCWs and on 25 February 2021, for the unvaccinated group. The incidence rate ratio was calculated to estimate the unadjusted effectiveness. Cox regression was used to adjust the effectiveness of CoronaVac. Results & Conclusion: The adjusted effectiveness of CoronaVac against COVID-19 was 65% (95% CI: 50-75%). Compared with the results of the phase III trial conducted in Turkey, a lower effectiveness of CoronaVac against COVID-19 was detected in this real-life study. This finding suggests that mass vaccination and booster doses are needed.