Akademik Veri Yönetim Sistemi
Osmangazi Tıp Dergisi, cilt.43, sa.3, ss.239-246, 2021 (Hakemli Dergi)
Abstract: The aim of this study was to evaluate the attenuated live vaccine administration before and after liver transplantation. This study
was carried out at the Child Health Surveillance Unit of the Social Pediatrics Department. Besides healthy children, children with special
needs are being followed-up at the Unit. Each child has a personal health record in the unit. The health records of patients who had received
attenuated live vaccine before liver transplantation under 1 year of age or after liver transplantation were evaluated. Demographic
characteristics, data showing immunologic status before vaccination, vaccine related reactions and serologic responses were obtained from
health records of each child. Retrospective files of 5 patients who were in follow-up were examined. Four patients at least 2 years after the
liver transplantation had attenuated live vaccination (measles-mumps-rubella vaccine and / or chickenpox vaccine). No adverse reaction was
noted after the immunization among these 4 children. A 6-month-15-day-old infant who was a candidate for liver transplantation had been
vaccinated with measles-mumps-rubella and chickenpox vaccine and it was determined that the serological response after vaccination was
not complete in the baby who did not have any adverse reactions after vaccination. Our findings demonstrated that despite the use of
immusuppressive therapy, it is safe to apply attenuated live vaccines after the transplantation if appropriate conditions were provided. The
timing of the rapid effective immunization before transplantation under one year of age needs to be further investigated.
Keywords: Child, liver transplantation, attenuated live vaccination