Akademik Veri Yönetim Sistemi
Journal of Research in Pharmacy, cilt.30, sa.3, ss.843-852, 2026 (ESCI, Scopus, TRDizin)
The study aimed to evaluate and compare the performance of different ready-to-use excipients in the formulation of Deferasirox (DFX) orally disintegrating tablets (ODTs) using direct compression. Ready-to-use excipients, including Parteck® ODT, Kollitab™ DC 87 L, Ludiflash®, Ludipress® LCE, Parteck® M 200, Parteck® SI 150, Parteck® LUB MST were blended with Deferasirox. The blend consisting of eight different formulations was evaluated for powder properties, including angle of repose, bulk density, tapped density, Hausner's ratio, and compressibility index. The produced tablets were evaluated for tablet properties, including weight variation, breaking force, thickness, friability, disintegration test, and dissolution test. According to all the obtained results, none of the prepared formulations could fulfill the requirements needed to be applicable as an individual excipient of ODT. The formulations that could pass all the tests except the dissolution test were formulation (F5) Ludiflash® and formulation (F4) Kollitab™ DC 87 L. Ludiflash® could provide a drug release after 30 minutes of (45.62%), which was more than Kollitab™ DC 87 L, which provides (35.32%). These excipients cannot be used alone for ODTs. Further study is needed to optimize the formulations.