Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis

Ovadia C., Sajous J., Seed P. T., Patel K., Williamson N. J., Attilakos G., ...More

LANCET GASTROENTEROLOGY & HEPATOLOGY, vol.6, no.7, 2021 (SCI-Expanded) identifier identifier identifier identifier


Background Ursodeoxycholic acid is commonly used to treat intrahepatic cholestasis of pregnancy, yet its largest trial detected minimal benefit for a composite outcome (stillbirth, preterm birth, and neonatal unit admission). We aimed to examine whether ursodeoxycholic acid affects specific adverse perinatal outcomes.