Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis

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Ovadia C., Sajous J., Seed P. T., Patel K., Williamson N. J., Attilakos G., ...More

LANCET GASTROENTEROLOGY & HEPATOLOGY, vol.6, no.7, 2021 (SCI-Expanded)

• Publication Type: Article / Review
• Volume: 6 Issue: 7
• Publication Date: 2021
• Doi Number: 10.1016/s2468-1253(21)00074-1
• Journal Name: LANCET GASTROENTEROLOGY & HEPATOLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
• Istanbul University Affiliated: Yes

Abstract

Background Ursodeoxycholic acid is commonly used to treat intrahepatic cholestasis of pregnancy, yet its largest trial detected minimal benefit for a composite outcome (stillbirth, preterm birth, and neonatal unit admission). We aimed to examine whether ursodeoxycholic acid affects specific adverse perinatal outcomes.