Detection of Recurrent Parathyroid Cancer Using 68Ga-Trivehexin PET/CT

Denizmen Zorba D., Kuyumcu S., Kubat Uzum A., Isik E. G., Sanli Y.

Clinical Nuclear Medicine, vol.50, no.7, 2025 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 7
  • Publication Date: 2025
  • Doi Number: 10.1097/rlu.0000000000005735
  • Journal Name: Clinical Nuclear Medicine
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
  • Keywords: 68Ga-Trivehexin PET/CT, 99mTc-MIBI SPECT/CT, parathyroid carcinoma
  • Istanbul University Affiliated: Yes

Abstract

A 53-year-old woman with a history of multiple surgeries due to recurrent parathyroid carcinoma (rPTC) presented with elevated serum parathyroid hormone (PTH) and ionized calcium (Ca) levels. While 18F-FDG PET/CT showed no pathologic uptake and 99mTc-MIBI SPECT/CT showed a suspicious uptake, 68Ga-Trivehexin PET/CT revealed intense activity in the recurrent lesion, as well as mild activity in one of the newly detected, widespread lesions in both lungs, which was assessed as metastatic. This is the first case report demonstrating the potential role of 68Ga-Trivehexin PET/CT in detecting recurrent PTC, highlighting the possibility of false-negative results with 18F-FDG PET/CT and 99mTc-MIBI scintigraphy.