Nitric oxide mediated effects of nebivolol in cardiorenal syndrome

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Mercanoglu G., Semen O.

IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol.22, no.11, pp.1314-1324, 2019 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 22 Issue: 11
• Publication Date: 2019
• Doi Number: 10.22038/ijbms.2019.37400.8927
• Journal Name: IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.1314-1324
• Istanbul University Affiliated: Yes

Abstract

Objective(s): Despite several proposed mechanisms for the pathophysiology of cardiorenal syndrome (CRS), the exact mechanism remains unclear. Nitrosative stress has been argued as a key mechanism recently. Nebivolol is a beta-blocker with nitric oxide (NO)-releasing effect. In the present study, NO-mediated effects of two different treatment regimes of nebivolol in CRS were studied.