Nitric oxide mediated effects of nebivolol in cardiorenal syndrome

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Mercanoglu G., Semen O.

IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, cilt.22, sa.11, ss.1314-1324, 2019 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 22 Sayı: 11
• Basım Tarihi: 2019
• Doi Numarası: 10.22038/ijbms.2019.37400.8927
• Dergi Adı: IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.1314-1324
• İstanbul Üniversitesi Adresli: Evet

Özet

Objective(s): Despite several proposed mechanisms for the pathophysiology of cardiorenal syndrome (CRS), the exact mechanism remains unclear. Nitrosative stress has been argued as a key mechanism recently. Nebivolol is a beta-blocker with nitric oxide (NO)-releasing effect. In the present study, NO-mediated effects of two different treatment regimes of nebivolol in CRS were studied.