Akademik Veri Yönetim Sistemi
Alzheimer’s Disease: From Molecular Mechanisms to Clinical Practices, Dildar Konukoğlu, Editör, Nobel Yayınevi, İstanbul, ss.175-187, 2024
ABSTRACT
This century, the extended
lifespans of individuals have made Alzheimer's disease (AD) and other
age-related diseases a significant challenge for modern healthcare systems. The
risk of developing AD increases with age, particularly for those over 60 to 65,
and it becomes the most common form of dementia in individuals above 85. Today,
the diagnosis of AD depends on clinical findings, neuroimaging techniques, and
amyloid positron emission tomography (PET). While genetic testing can be
helpful in rare, monogenic forms, its utility for diagnosing the common types
is very limited. Large-scale projects like "All of Us" aim to improve
the accuracy of polygenic risk scores for complex diseases encompassing
multigenic and multifactorial nature by analyzing vast amounts of genetic data.
Future initiatives, such as Fourth Generation Sequencing, aim to integrate
genomic and transcriptomic data, holding promise for earlier diagnosis and
prevention, potentially saving cognitive function and improving the health of
elderly individuals.