Atıf İçin Kopyala
Esen F., Erdem T. L., Aktan D., Orhan M., Kaya M., Eraksoy H., ...Daha Fazla
CRITICAL CARE, cilt.9, sa.1, 2005 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
9
Sayı:
1
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Basım Tarihi:
2005
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Doi Numarası:
10.1186/cc3004
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Dergi Adı:
CRITICAL CARE
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Anahtar Kelimeler:
blood-brain barrier, brain edema, magnesium, sepsis, septic encephalopathy, CLOSED-HEAD INJURY, SEPTIC ENCEPHALOPATHY, CEREBRAL EDEMA, PERMEABILITY, THERAPY
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İstanbul Üniversitesi Adresli:
Evet
Özet
Introduction Permeability changes in the blood - brain barrier (BBB) and their possible contribution to brain edema formation have a crucial role in the pathophysiology of septic encephalopathy. Magnesium sulfate has been shown to have a protective effect on BBB integrity in multiple experimental models. In this study we determine whether magnesium sulfate administration could have any protective effects on BBB derangement in a rat model of sepsis.