Effect of magnesium sulfate administration on blood-brain barrier in a rat model of intraperitoneal sepsis: a randomized controlled experimental study
CRITICAL CARE, cilt.9, sa.1, 2005 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 9 Sayı: 1
- Basım Tarihi: 2005
- Doi Numarası: 10.1186/cc3004
- Dergi Adı: CRITICAL CARE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Anahtar Kelimeler: blood-brain barrier, brain edema, magnesium, sepsis, septic encephalopathy, CLOSED-HEAD INJURY, SEPTIC ENCEPHALOPATHY, CEREBRAL EDEMA, PERMEABILITY, THERAPY
- İstanbul Üniversitesi Adresli: Evet
Özet
Introduction Permeability changes in the blood - brain barrier (BBB) and their possible contribution to brain edema formation have a crucial role in the pathophysiology of septic encephalopathy. Magnesium sulfate has been shown to have a protective effect on BBB integrity in multiple experimental models. In this study we determine whether magnesium sulfate administration could have any protective effects on BBB derangement in a rat model of sepsis.