Effect of magnesium sulfate administration on blood-brain barrier in a rat model of intraperitoneal sepsis: a randomized controlled experimental study

Esen F., Erdem T. L., Aktan D., Orhan M., Kaya M., Eraksoy H., ...Daha Fazla

CRITICAL CARE, cilt.9, sa.1, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 1
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1186/cc3004
  • Dergi Adı: CRITICAL CARE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: blood-brain barrier, brain edema, magnesium, sepsis, septic encephalopathy, CLOSED-HEAD INJURY, SEPTIC ENCEPHALOPATHY, CEREBRAL EDEMA, PERMEABILITY, THERAPY
  • İstanbul Üniversitesi Adresli: Evet

Özet

Introduction Permeability changes in the blood - brain barrier (BBB) and their possible contribution to brain edema formation have a crucial role in the pathophysiology of septic encephalopathy. Magnesium sulfate has been shown to have a protective effect on BBB integrity in multiple experimental models. In this study we determine whether magnesium sulfate administration could have any protective effects on BBB derangement in a rat model of sepsis.