Methiocarb-induced oxidative damage following subacute exposure and the protective effects of vitamin E and taurine in rats


Ozden S., Catalgol B., Gezginci-Oktayoglu S., Arda-Pirincci P., Bolkent S., Alpertunga B.

FOOD AND CHEMICAL TOXICOLOGY, vol.47, no.7, pp.1676-1684, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 7
  • Publication Date: 2009
  • Doi Number: 10.1016/j.fct.2009.04.018
  • Journal Name: FOOD AND CHEMICAL TOXICOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1676-1684
  • Keywords: Methiocarb, Vitamin E, Taurine, Oxidative damage, Liver and kidney injury, FLAVIN-CONTAINING MONOOXYGENASE, N-METHYLCARBAMATE PESTICIDES, GLUTATHIONE REDOX SYSTEM, LIPID-PEROXIDATION, ALPHA-TOCOPHEROL, IN-VIVO, ORGANOPHOSPHATE INSECTICIDE, ANTIOXIDANT DEFENSE, THIOETHER COMPOUNDS, INDUCED TOXICITY
  • Istanbul University Affiliated: Yes

Abstract

Methiocarb, is used worldwide in agriculture and health programs. Besides its advantages in the agriculture, it causes several toxic effects. In this study, we aimed to investigate subacute effects of methiocarb on lipid peroxidation, reduced glutathione (GSH), antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and glutathione reductase (GSH-Rd) and histopathological changes in rat tissues. Moreover, we examined the possible protective effects of vitamin E and taurine on methiocarb-induced oxidative damage in rat tissues. Rats were randomly divided into six groups as follows; I-control group; II-methiocarb group; III-vitamin E group; IV-vitamin E + methiocarb group; V-taurine group and VI-taurine + methiocarb group. Methiocarb significantly increased lipid peroxidation in liver and kidney when compared to control groups. Levels of GSH and activities of SOD, CAT and GSH-Px were found to be decreased, while GSH-Rd remained unchanged in rat liver and kidney treated with methiocarb. Pretreatment of vitamin E and taurine resulted in a significant decrease on lipid peroxidation, alleviating effects on GSH and antioxidant enzymes. The degenerative histological changes were less in liver than kidney of rats treated with methiocarb. Pretreatment of vitamin E and taurine showed a protective effect on the histological changes in kidney comparing to the liver of rats treated with methiocarb. (C) 2009 Elsevier Ltd. All rights reserved.