Serum interleukin 1 alpha and interleukin 2 levels in patients with schizophrenia

Ebrinc S., Top C., Oncul O., Basoglu C., Cavuslu S., Cetin M.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, cilt.30, sa.3, ss.314-317, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 3
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1177/147323000203000313
  • Dergi Adı: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.314-317
  • Anahtar Kelimeler: schizophrenia, interleukin 1 alpha, interleukin 2, INFLAMMATORY RESPONSE SYSTEM, CYTOKINE PRODUCTION, CSF LEVELS, DRUG-FREE, RESISTANT, CULTURES
  • İstanbul Üniversitesi Adresli: Evet

Özet

It has been suggested that altered interleukin (IL) regulation may be involved in the pathogenesis of schizophrenia. In this cross-sectional, case-controlled study, patients with schizophrenia and a control group of healthy subjects, matched by age, sex and body mass index, were evaluated. The levels of IL-1alpha and IL-2 in blood serum were measured by enzyme-linked immunosorbent assay. The fasting serum IL-2 levels were significantly higher in patients with schizophrenia compared with the control subjects, but there was no difference between the fasting serum levels of IL-1alpha in patients with schizophrenia and the control subjects. Our results suggest that patients with schizophrenia have altered IL-2, but not IL-1alpha, regulation.