Serum interleukin 1 alpha and interleukin 2 levels in patients with schizophrenia

Ebrinc S., Top C., Oncul O., Basoglu C., Cavuslu S., Cetin M.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, vol.30, no.3, pp.314-317, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 3
  • Publication Date: 2002
  • Doi Number: 10.1177/147323000203000313
  • Journal Name: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.314-317
  • Keywords: schizophrenia, interleukin 1 alpha, interleukin 2, INFLAMMATORY RESPONSE SYSTEM, CYTOKINE PRODUCTION, CSF LEVELS, DRUG-FREE, RESISTANT, CULTURES
  • Istanbul University Affiliated: Yes

Abstract

It has been suggested that altered interleukin (IL) regulation may be involved in the pathogenesis of schizophrenia. In this cross-sectional, case-controlled study, patients with schizophrenia and a control group of healthy subjects, matched by age, sex and body mass index, were evaluated. The levels of IL-1alpha and IL-2 in blood serum were measured by enzyme-linked immunosorbent assay. The fasting serum IL-2 levels were significantly higher in patients with schizophrenia compared with the control subjects, but there was no difference between the fasting serum levels of IL-1alpha in patients with schizophrenia and the control subjects. Our results suggest that patients with schizophrenia have altered IL-2, but not IL-1alpha, regulation.