Prognostic value of proliferating cell nuclear antigen immunostaining in pediatric rhabdomyosarcomas

Tokuc G., Dogan O., Ayan I., Kebudi R., Dogan S., Demiryont M., ...Daha Fazla

ACTA PAEDIATRICA JAPONICA, cilt.40, sa.6, ss.573-579, 1998 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 6
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1111/j.1442-200x.1998.tb01993.x
  • Dergi Adı: ACTA PAEDIATRICA JAPONICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.573-579
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: The levels of proliferating cell nuclear antigen (PCNA) are almost negligible in long-term quiescent cells and increase dramatically during the cell cycle. Recently, the monoclonal antibodies to PCNA have been used to demonstrate the proliferative component of paraffin-embedded tumor tissues. It has been shown to be available as a simple histological marker of proliferative activity and the PCNA labeling index has been correlated with the prognosis of several malignant neoplasms.