Research Information System
BMC CANCER, vol.22, no.1, 2022 (SCI-Expanded)
Aim: The purpose was to provide a practical and effective method for performing reliable Y-90 dosimetry based on Tc-99m-MAA and SPEC/CT. The impact of scatter correction (SC) and attenuation correction (AC) on the injected Y-90 activity, lung shunt fraction (LSF) and the delivered dose to lung and liver compartments was investigated within the scope of the study. Material and methods: Eighteen eligible patients (F: 3, M: 15) were subjected to Y-90 therapy. Tc-99m-MAA (111-222 MBq) was injected into the targeted liver, followed by whole-body scan (WBS) with peak-window at 140 keV (15% width) and one down-scatter window. SPECT/CT scan was subsequently acquired encompassing lung and liver regions. The LSFs were fashioned from standard WBS LSFwb (St), scatter corrected WBS LSFwb (Sc), only scatter corrected SPECT LSFspect (NoAC-SC) and SPECT/CT with attenuation and scatter correction LSFspect (AC-SC). The absorbed doses that would be delivered to tumor and injected healthy liver were estimated using different calculation modes involving AC-SC (SPECT/CT), NoAC-SC (SPECT), NoAC-NoSC+LSFwb (SC), AC-SC + LSFwb (St), and NoAC-NoSC+LSFwb (St). Results: The average deviations (range) in LSF values between standard LSFwb (St) and those from SPECT/CT (ACSC), SPECT (NoAC-SC), and LSFwb (SC) were - 50% (-29/-71), - 32% (-8/-67), and - 45% (-13/80),respectively. The suggested Y-90 activity (GBq/Gy) was decreased within a range of 2-11%, 1-9%, and 2-7% by using LSFspect (ACSC), LSFspect (NoAC-SC), and LSFwb (SC), respectively. Overall, two-sample t-test yielded no statistically significant difference (p < 0.05) in the absorbed doses to tumor and injected healthy liver between AC-SC (SPECT) and the rest of approaches with/and without AC and SC. However, a statistically significant difference (p < 0.05) was demonstrated in the lung shunt fractions and lung doses due to AC and SC. The LSFs from scatter corrected planar images LSFwb (SC) exhibited well agreement (R-2 = 0.92) with SPECT/CT (AC-SC) and there was no statistically significant difference (P-value > 0.05) between both methods. Conclusion: It was deduced that SPECT/CT with attenuation and scatter correction plays a crucial role in the measurements of lung shunt fraction and dose as well as the total number of Y-90 treatments. However, the absorbed dose to tumors and injected healthy liver was minimally affected by AC and SC. Besides, a good agreement was observed between LSF datasets from SPECT/CT versus scatter corrected WBS that can be alternatively and effectively used in Y-90 dosimetry.