Are sample sizes of randomized clinical trials in rheumatoid arthritis too large?


Celik S., Yazici Y., Yazici H.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, vol.44, no.11, pp.1034-1044, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 11
  • Publication Date: 2014
  • Doi Number: 10.1111/eci.12337
  • Journal Name: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1034-1044
  • Istanbul University Affiliated: No

Abstract

ObjectiveWe had the impression that randomized clinical trials (RCTs) frequently over enrolled patients. Thus, we surveyed power calculations in publications of RCTs of biologics in rheumatoid arthritis (RA) to assess over enrollment.