Are sample sizes of randomized clinical trials in rheumatoid arthritis too large?

Celik S., Yazici Y., Yazici H.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, cilt.44, sa.11, ss.1034-1044, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 11
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1111/eci.12337
  • Dergi Adı: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1034-1044
  • İstanbul Üniversitesi Adresli: Hayır

Özet

ObjectiveWe had the impression that randomized clinical trials (RCTs) frequently over enrolled patients. Thus, we surveyed power calculations in publications of RCTs of biologics in rheumatoid arthritis (RA) to assess over enrollment.