Effects of nitrendipine on reference and working memory of rats in three-panel runway

Celik P., Uresin Y., Tonyali H.

PHARMACOLOGICAL RESEARCH, cilt.50, sa.3, ss.367-370, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 3
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1016/j.phrs.2004.01.014
  • Dergi Adı: PHARMACOLOGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.367-370
  • İstanbul Üniversitesi Adresli: Evet

Özet

This study was designed to investigate whether calcium-channel blocker, nitrendipine affects memory of rats in three-panel runway test. Nitrendipine (2-4 mg kg(-1), intra peritoneally (i.p.)) neither enhanced nor impaired reference and working memory performances of young adult rats. However, it improved impairment in reference memory induced by anticholinergic drug scopolamine (3 mg kg(-1), i.p.) while it had no effects on impairment in working memory induced by the same drug. The results suggest that nitrendipine may be of benefit in the treatment of memory disturbances resulted from cholinergic deficit. (C) 2004 Elsevier Ltd. All rights reserved.