Synthesis and antimicrobial activity of new tetrahydro-2H-1,3,5-thiadizine-2-thione derivatives

Ilhan E., Capan G., Ergenc N., Uzun M., Kiraz M., Kaya D.

Farmaco, cilt.50, ss.787-790, 1995 (SCI Expanded İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 50 Konu: 11
  • Basım Tarihi: 1995
  • Dergi Adı: Farmaco
  • Sayfa Sayıları: ss.787-790


A series of 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thiones was synthesized and evaluated for antibacterial and antifungal activity. All of the tested compounds were found active against,Staphylococcus aureus and Staphylococcus epidermidis. The compounds were also active against yeast-like fungi and molds where the anticandidal activity of 3a against Candida albicans was superior to the standards miconazole and clotrimazole.