Cabergoline (CAB) is an ergot alkaloid derivative with dopamine agonist activity. A novel, simple, and rapid stability-indicating high-performance liquid chromatographic (HPLC) method for assay of CAB in tablets has been developed and validated. Chromatography was performed on a 4.6 mm i.d. x 250 mm, 5 mu m particle, cyano column with acetonitrile-10 mM phosphoric acid, 35:65 (v/v), containing 0.04% triethylamine, as mobile phase, at a flow rate of 1.0 mL min(-1), and UV detection at 280 nm. Response was a linear function of concentration in the range 0.1-4 mu g mL(-1) (r(2) = 0.9999). The recovery of the method was good (99.45%) and RSD values for intra-day and inter-day precision were 0.24-0.88% and 0.66-1.19%, respectively. The method can be used for quality-control assay of CAB in tablets, for stability studies, and for in vitro dissolution studies.