Intracellular trafficking of diphtheria toxin and its mutated form, CRM197, in the endocytic pathway

Edis B., Haciosmanoglu E., Varol B., Bektas M.

NORTHERN CLINICS OF ISTANBUL, vol.5, no.2, pp.89-95, 2018 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 5 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.14744/nci.2017.55798
  • Journal Name: NORTHERN CLINICS OF ISTANBUL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.89-95
  • Istanbul University Affiliated: Yes

Abstract

OBJECTIVE: Diphtheria toxin (DTx) is a well-characterized bacterial toxin. However, the endocytic pathway of the mutant of DTx, CRM197, which is used as an immunological adjuvant, has not yet been fully explained. The aim of this study was to investigate the intracellular trafficking of CRM197-loaded endosomes.