Intracellular trafficking of diphtheria toxin and its mutated form, CRM197, in the endocytic pathway

Edis B., Haciosmanoglu E., Varol B., Bektas M.

NORTHERN CLINICS OF ISTANBUL, cilt.5, sa.2, ss.89-95, 2018 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 5 Sayı: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.14744/nci.2017.55798
  • Dergi Adı: NORTHERN CLINICS OF ISTANBUL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.89-95
  • İstanbul Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Diphtheria toxin (DTx) is a well-characterized bacterial toxin. However, the endocytic pathway of the mutant of DTx, CRM197, which is used as an immunological adjuvant, has not yet been fully explained. The aim of this study was to investigate the intracellular trafficking of CRM197-loaded endosomes.