Investigation of ABCA1 C69T polymorphism in patients with type 2 diabetes mellitus.

Ergen H. A., Zeybek U., Gok O., Karaali Z. E.

Biochemia medica, vol.22, no.1, pp.114-20, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 1
  • Publication Date: 2012
  • Doi Number: 10.11613/bm.2012.013
  • Journal Name: Biochemia medica
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.114-20
  • Keywords: diabetes mellitus, lipoproteins, high density lipoprotein, dyslipidemia, polymorphism, genetic, DENSITY-LIPOPROTEIN-CHOLESTEROL, CASSETTE TRANSPORTER A1, HDL-CHOLESTEROL, DISEASE, VARIANT, PLASMA, GENE, ASSOCIATION, RISK, POPULATION
  • Istanbul University Affiliated: Yes

Abstract

Introduction: Non insulin dependent diabetes mellitus is the most common type of diabetes. Genetic factors, lipid profiles, hypertension are potential risk factors for diabetes mellitus. Adenosine binding cassette transporter proteins 1 (ABCA1) plays a role in cholesterol metabolism, especially high density lipoprotein (HDL-cholesterol). There are multiple mechanisms by which HDL-cholesterol can be atheroprotective, it is clear that the relative activity of ABCA1 plays a major role. We aimed to investigate association of ABCA1 C69T gene polymorphism with lipid levels in Turkish type 2 diabetic patients.