Antidepressant-like Effects Induced by Chronic Blockade of the Purinergic 2X7 Receptor through Inhibition of Non-like Receptor Protein 1 Inflammasome in Chronic Unpredictable Mild Stress Model of Depression in Rats
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, cilt.17, sa.2, ss.261-272, 2019 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 17 Sayı: 2
- Basım Tarihi: 2019
- Doi Numarası: 10.9758/cpn.2019.17.2.261
- Dergi Adı: CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.261-272
- Anahtar Kelimeler: Depression, Coomassie Brilliant Blue, ATP receptor, Purinergic P2X7 receptors, Animal models, BRILLIANT BLUE G, NLRP3 INFLAMMASOME, P2RX7 GENE, GLN460ARG POLYMORPHISM, MICROGLIAL ACTIVATION, PSYCHOLOGICAL STRESS, ANIMAL-MODELS, GLOBAL BURDEN, MOUSE MODEL, PATHOPHYSIOLOGY
- İstanbul Üniversitesi Adresli: Evet
Özet
Objective: Purinergic 2X7 receptor (P2X7R) activation is known to be involved in pathogenesis of depression. Our aims were to investigate P2X7R-activated inflammasome pathways in parallel with induction of depression and to test the antidepressant-like effects of the selective P2X7R antagonist Brilliant Blue G (BBG) in a rat model of chronic unpredictable mild stress (CUMS).