Kappa/Lambda Light-chain Typing in Alzheimer's Disease


Kaya Z. Z. , Tuzuner M. B. , Sahin B., Akgun E., AKSUNGAR F., Koca S., ...More

CURRENT ALZHEIMER RESEARCH, vol.19, no.1, pp.84-93, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 1
  • Publication Date: 2022
  • Doi Number: 10.2174/1567205019666220131101334
  • Journal Name: CURRENT ALZHEIMER RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Abstracts in Social Gerontology, Chemical Abstracts Core, EMBASE, MEDLINE, Psycinfo
  • Page Numbers: pp.84-93
  • Keywords: Alzheimer's disease, MALDI-TOF-MS, screening tool, microaffinity chromatography, affinity capture resins, kappa light chain, ratio, lambda light chain ratio, PLASMA NEUROFILAMENT LIGHT, FOLLOW-UP, ELECTROPHORESIS, BIOMARKERS, PROTEINS, QUANTIFICATION, PURIFICATION, PROGNOSIS, DISCOVERY, DIAGNOSIS
  • Istanbul University Affiliated: Yes

Abstract

Background: Alzheimer's disease is a progressive neurodegenerative disorder characterized by memory loss and cognitive impairment. The diagnosis of Alzheimer's disease according to symptomatic events is still a puzzling task. Developing a biomarker-based, low-cost, and high-throughput test, readily applicable in clinical laboratories, dramatically impacts the rapid and reliable detection of the disease.