Kappa/Lambda Light-chain Typing in Alzheimer's Disease

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Kaya Z. Z., Tuzuner M. B., Sahin B., Akgun E., AKSUNGAR F., Koca S., ...Daha Fazla

CURRENT ALZHEIMER RESEARCH, cilt.19, sa.1, ss.84-93, 2022 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 19 Sayı: 1
• Basım Tarihi: 2022
• Doi Numarası: 10.2174/1567205019666220131101334
• Dergi Adı: CURRENT ALZHEIMER RESEARCH
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Abstracts in Social Gerontology, Chemical Abstracts Core, EMBASE, MEDLINE, Psycinfo
• Sayfa Sayıları: ss.84-93
• Anahtar Kelimeler: Alzheimer's disease, MALDI-TOF-MS, screening tool, microaffinity chromatography, affinity capture resins, kappa light chain, ratio, lambda light chain ratio, PLASMA NEUROFILAMENT LIGHT, FOLLOW-UP, ELECTROPHORESIS, BIOMARKERS, PROTEINS, QUANTIFICATION, PURIFICATION, PROGNOSIS, DISCOVERY, DIAGNOSIS
• İstanbul Üniversitesi Adresli: Evet

Özet

Background: Alzheimer's disease is a progressive neurodegenerative disorder characterized by memory loss and cognitive impairment. The diagnosis of Alzheimer's disease according to symptomatic events is still a puzzling task. Developing a biomarker-based, low-cost, and high-throughput test, readily applicable in clinical laboratories, dramatically impacts the rapid and reliable detection of the disease.