Development and validation of a UV-Radio-HPLC method to assess chemical and radiochemical purity of [68Ga] Ga-PSMA-11
APPLIED RADIATION AND ISOTOPES, cilt.190, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 190
- Basım Tarihi: 2022
- Doi Numarası: 10.1016/j.apradiso.2022.110487
- Dergi Adı: APPLIED RADIATION AND ISOTOPES
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), Chemical Abstracts Core, Chimica, Compendex, EMBASE, Food Science & Technology Abstracts, INSPEC, MEDLINE, Pollution Abstracts
- Anahtar Kelimeler: Radio-HPLC, Radiochemical purity, Radiopharmaceutical, Prostate cancer, 68Ga]Ga-PSMA-11, PRESSURE LIQUID-CHROMATOGRAPHY, REVERSED-PHASE, GA-68, RADIOPHARMACEUTICALS, PEPTIDES
- İstanbul Üniversitesi Adresli: Evet
Özet
[68Ga]Ga-PSMA-11, a urea-based peptidomimetic, has been widely used in recent years for PET imaging of patients with prostate cancer. Since it has short half-life and should be in-house synthesized, synthesis conditions may affect quality and in vivo behavior of [68Ga]Ga-PSMA-11. Therefore in this study we aimed to develop an alternative, simple and validated HPLC method to test chemical and radiochemical purity of [68Ga]Ga-PSMA-11 for clinical routine.