Atıf İçin Kopyala
Pehlivanoglu H., Ocak M., Caglar-Andac S.
APPLIED RADIATION AND ISOTOPES, cilt.190, 2022 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
190
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Basım Tarihi:
2022
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Doi Numarası:
10.1016/j.apradiso.2022.110487
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Dergi Adı:
APPLIED RADIATION AND ISOTOPES
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), Chemical Abstracts Core, Chimica, Compendex, EMBASE, Food Science & Technology Abstracts, INSPEC, MEDLINE, Pollution Abstracts
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Anahtar Kelimeler:
Radio-HPLC, Radiochemical purity, Radiopharmaceutical, Prostate cancer, 68Ga]Ga-PSMA-11, PRESSURE LIQUID-CHROMATOGRAPHY, REVERSED-PHASE, GA-68, RADIOPHARMACEUTICALS, PEPTIDES
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İstanbul Üniversitesi Adresli:
Evet
Özet
[68Ga]Ga-PSMA-11, a urea-based peptidomimetic, has been widely used in recent years for PET imaging of patients with prostate cancer. Since it has short half-life and should be in-house synthesized, synthesis conditions may affect quality and in vivo behavior of [68Ga]Ga-PSMA-11. Therefore in this study we aimed to develop an alternative, simple and validated HPLC method to test chemical and radiochemical purity of [68Ga]Ga-PSMA-11 for clinical routine.