Development and validation of a UV-Radio-HPLC method to assess chemical and radiochemical purity of [68Ga] Ga-PSMA-11

Pehlivanoglu H., Ocak M., Caglar-Andac S.

APPLIED RADIATION AND ISOTOPES, vol.190, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 190
  • Publication Date: 2022
  • Doi Number: 10.1016/j.apradiso.2022.110487
  • Journal Name: APPLIED RADIATION AND ISOTOPES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), Chemical Abstracts Core, Chimica, Compendex, EMBASE, Food Science & Technology Abstracts, INSPEC, MEDLINE, Pollution Abstracts
  • Keywords: Radio-HPLC, Radiochemical purity, Radiopharmaceutical, Prostate cancer, 68Ga]Ga-PSMA-11, PRESSURE LIQUID-CHROMATOGRAPHY, REVERSED-PHASE, GA-68, RADIOPHARMACEUTICALS, PEPTIDES
  • Istanbul University Affiliated: Yes

Abstract

[68Ga]Ga-PSMA-11, a urea-based peptidomimetic, has been widely used in recent years for PET imaging of patients with prostate cancer. Since it has short half-life and should be in-house synthesized, synthesis conditions may affect quality and in vivo behavior of [68Ga]Ga-PSMA-11. Therefore in this study we aimed to develop an alternative, simple and validated HPLC method to test chemical and radiochemical purity of [68Ga]Ga-PSMA-11 for clinical routine.